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Literature summary for 3.4.22.B72 extracted from

  • Han, Y.; Huang, C.; Sun, X.; Xiang, B.; Wang, M.; Yeh, E.T.; Chen, Y.; Li, H.; Shi, G.; Cang, H.; Sun, Y.; Wang, J.; Wang, W.; Gao, F.; Yi, J.
    SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress (2010), J. Biol. Chem., 285, 12906-12915.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B72

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm weak expression in cytoplasm Homo sapiens 5737
-
nucleus predominantly localized in the nucleus Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(SUMO-2/3)-promyelocytic leukemia protein + H2O Homo sapiens SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress SUMO-2/3 + promyelocytic leukemia protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H4L4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic adenocarcinoma cell SENP3 is over-accumulated in a variety of primary human cancers including colon adenocarcinoma. SENP3-mediated de-SUMO2/3 of promyelocytic leukemia might contribute to the development or progression of human cancers Homo sapiens
-
HeLa cell
-
 Homo sapiens
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HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-2/3)-promyelocytic leukemia protein + H2O
-
 Homo sapiens SUMO-2/3 + promyelocytic leukemia protein
-
 ?
(SUMO-2/3)-promyelocytic leukemia protein + H2O SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein. SENP3-mediated de-conjugation of SUMO2/3 from PML is responsible for accelerated cell proliferation and decreased promyelocytic leukemia bodies under mild oxidative stress Homo sapiens SUMO-2/3 + promyelocytic leukemia protein
-
 ?

Synonyms

Synonyms Comment Organism
SENP3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens low doses of hydrogen peroxide induce an increase of the SENP3 protein up
Homo sapiens SENP3 is over-accumulated in a variety of primary human cancers including colon adenocarcinoma up

General Information

General Information Comment Organism
physiological function SENP3 appears to be a key mediator in mild oxidative stress-induced cell proliferation via regulation of the SUMOylation status of promyelocytic leukemia protein Homo sapiens