Literature summary for 3.4.22.B72 extracted from

Huang, C.; Han, Y.; Wang, Y.; Sun, X.; Yan, S.; Yeh, E.T.; Chen, Y.; Cang, H.; Li, H.; Shi, G.; Cheng, J.; Tang, X.; Yi, J.
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation (2009), EMBO J., 28, 2748-2762.

Search for more literature for 3.4.22.B72

General Stability

General Stability	Organism
SENP3 is continuously degraded through the ubiquitin proteasome pathway under basal condition. Reactive oxygen species inhibit this degradation	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleolus	reactive oxygen species cause SENP3 to redistribute from the nucleoli to the nucleoplasm, allowing it to regulate nuclear events	Homo sapiens	5730	-
nucleoplasm	reactive oxygen species cause SENP3 to redistribute from the nucleoli to the nucleoplasm, allowing it to regulate nuclear events	Homo sapiens	5654	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(SUMO-2)-p300 protein + H2O	Homo sapiens	removing SUMO2/3 from p300 enhances its binding to HIF-1alpha. SENP3 is a redox sensor that regulates hypoxia-inducible factor-1alpha transcriptional activity under oxidative stress through the de-SUMOylation of p300	(SUMO-2) + p300 protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H4L4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(SUMO-2)-p300 protein + H2O	-	Homo sapiens	(SUMO-2) + p300 protein	-	?
(SUMO-2)-p300 protein + H2O	removing SUMO2/3 from p300 enhances its binding to HIF-1alpha. SENP3 is a redox sensor that regulates hypoxia-inducible factor-1alpha transcriptional activity under oxidative stress through the de-SUMOylation of p300	Homo sapiens	(SUMO-2) + p300 protein	-	?
(SUMO-3)-hypoxia-inducible factor-1alpha protein + H2O	SENP3 can remove SUMO3, but not SUMO1 from hypoxia-inducible factor-1alpha protein	Homo sapiens	SUMO-3 + hypoxia-inducible factor-1alpha protein	-	?

Synonyms

Synonyms	Comment	Organism
SENP3	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression of SUMO2/3-specific protease, SENP3 increases after treatment with 50 mM H2O2, and this increase occurs in a dose-dependent manner	up

General Information

General Information	Comment	Organism
physiological function	SENP3 is a redox sensor that regulates hypoxia-inducible factor-1alpha transcriptional activity under oxidative stress through the de-SUMOylation of p300	Homo sapiens

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Release 2023.1 (January 2023)