Organism | UniProt | Comment | Textmining |
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Murine coronavirus | - |
- |
- |
Synonyms | Comment | Organism |
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PLP2 | - |
Murine coronavirus |
General Information | Comment | Organism |
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physiological function | changes within the Ubl domain, residues 785 to 787 of nonstructural protein 3, negatively affect protease activity. Ubl mutant viruses V787S and V785S replicate efficiently at 37°C but generate smaller plaques than wild-type virus, and V787S is defective for replication at higher temperatures. The proteases of the mutant viruses exhibit similar specific activities at 25°C but diplay significantly reduced thermal stability at 30°C, thereby reducing the total enzymatic activity. Infection of C57BL/6 mice with V787S is highly attenuated, yet it replicates sufficiently to elicit protective immunity | Murine coronavirus |