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Literature summary for 3.4.22.B50 extracted from

  • Kanjanahaluethai, A.; Baker, S.C.
    Identification of mouse hepatitis virus papain-like proteinase 2 activity (2000), J. Virol., 74, 7911-7921.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B50

Cloned(Commentary)

Cloned (Comment) Organism
-
 Murine coronavirus

Inhibitors

Inhibitors Comment Organism Structure
additional information not sensitive to cysteine protease inhibitor E64d Murine coronavirus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Murine coronavirus the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein ?
-
 ?
replicase polyprotein + H2O Murine coronavirus PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans ?
-
 ?

Organism

Organism UniProt Comment Textmining
Murine coronavirus
-
 i.e. mouse hepatitis virus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Cys1715 is a catalytic residue of PLP2 Murine coronavirus ?
-
 ?
additional information the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein Murine coronavirus ?
-
 ?
replicase polyprotein + H2O PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans Murine coronavirus ?
-
 ?