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Literature summary for 3.4.22.B5 extracted from

  • Mottram, J.C.; Frame, M.J.; Brooks, D.R.; Tetley, L.; Hutchison, J.E.; Souza, A.E.; Coombs, G.H.
    The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferences (1997), J. Biol. Chem., 272, 14285-14293.
    View publication on PubMed
Search for more literature for 3.4.22.B5

Localization

Localization Comment Organism GeneOntology No. Textmining
megasome isoenzyme CPB2.8 and CPB1 Leishmania mexicana 43246
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Leishmania mexicana individual isoenzymes have distinct roles in the parasite‘s interaction with its host ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania mexicana P36400
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information individual isoenzymes have distinct roles in the parasite‘s interaction with its host Leishmania mexicana ?
-
 ?
N-benzoyl-Phe-Val-Arg-7-amido-4-methylcoumarin + H2O isoenzyme CPB1, CPB2.8 and CPB18 show almost proficient hydrolyzing activity Leishmania mexicana N-benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
 ?
N-succinyl-Leu-Tyr-7-amido-4-methylcoumarin + H2O isoenzyme CPB18 has significant higher activity than isoenzymes CPB1 or CPB2.8 Leishmania mexicana N-succinyl-Leu-Tyr + 7-amino-4-methylcoumarin
-
 ?

pI Value

Organism Comment pI Value Maximum pI Value
Leishmania mexicana isoenzyme CPB1
-
 4.34
Leishmania mexicana isoenzyme CPB19
-
 4.37
Leishmania mexicana isoenzyme CPB2.8
-
 4.83
Leishmania mexicana isoenzyme CPB18
-
 5.4