Literature summary for 3.4.22.B30 extracted from

Panico, P.; Salazar, A.M.; Burns, A.L.; Ostrosky-Wegman, P.
Role of calpain-10 in the development of diabetes mellitus and its complications (2014), Arch. Med. Res., 45, 103-115.

Search for more literature for 3.4.22.B30

Cloned(Commentary)

Cloned (Comment)	Organism
genotyping and association with type 2 diabetes mellitus , detailed overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	CAPN10 polymorphisms occur in the development of type 2 diabetes mellitus, ariation in the CAPN10 gene (SNP-43 G/G, InDel-19 3/2 and SNP-63 C/T) known as haplotype 121/112	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	dependent on, enzyme activity on SNAP-25 protein in response to calcium influx, resulting in the release of insulin	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
54000	-	x * 54000, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
SNAP-25 + H2O	Homo sapiens	the 54 kDa isoform of calpain-10 proteolyzes SNAP-25, a member of SNARE family of proteins involved in vesicle fusion	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC96	gene CAPN10	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	-	Homo sapiens	-
skeletal muscle	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SNAP-25 + H2O	the 54 kDa isoform of calpain-10 proteolyzes SNAP-25, a member of SNARE family of proteins involved in vesicle fusion	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 54000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
calpain-10	-	Homo sapiens
CAPN10	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	calpain-10 is overexpressed and activated through the inhibition of ryanodine receptor 2 under hypoglycemic and high fatty acid conditions, causing caspase-3-independent beta-cell death	up

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown in human primary muscle cells results in decreased insulin-stimulated glucose uptake and GLUT4 translocation to the plasma membrane through actin filament reorganization, with no changes in expression and activation of molecules involved in the insulin transduction pathway such as IRb, IRS1, IRS2 and Akt, or in glycogen synthesis. Calpain-10 is overexpressed and activated through the inhibition of ryanodine receptor 2 under hypoglycemic and high fatty acid conditions, causing caspase-3-independent beta-cell death	Homo sapiens
metabolism	associations of the CAPN10 gene with metabolic phenotypes, overview. Key participation of the enzyme in glucose metabolism, role of calpain-10 in the development of type 2 diabetes mellitus and diabetes-related diseases, detailed overview. Calpains might function as sensors of glucose-induced calcium currents, which culminate with insulin secretion	Homo sapiens
additional information	enzyme polymorphisms are associated with the risk of developing type 2 diabetes mellitus in Mexican-American populations with a high populationattributable risk	Homo sapiens
physiological function	calpain-10 is required to maintain proper mitochondrial function by proteolysis of complex I subunits and the beta subunit of ATP synthase. Calpain-10 is involved in insulin-dependent GLUT4 externalization in adipocytes and muscle cells. Calpain-10 participates in insulin-stimulated glucose uptake. Calpain-10 is implicated in the development of type 2 diabetes, and polymorphisms in the CAPN10 gene are associated with an increased risk of developing this disease	Homo sapiens

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Release 2023.1 (January 2023)