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Literature summary for 3.4.22.B30 extracted from

  • Diaz-Villasenor, A.; Burns, A.L.; Salazar, A.M.; Sordo, M.; Hiriart, M.; Cebrian, M.E.; Ostrosky-Wegman, P.
    Arsenite reduces insulin secretion in rat pancreatic beta-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25 (2008), Toxicol. Appl. Pharmacol., 231, 291-299.
    View publication on PubMed
Search for more literature for 3.4.22.B30

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 x * 50000, diverse isoforms of calpain-10 are produced by alternative splicing. The isoform that shows the highest levels of expression is the one of approximately 50000 Da Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SNAP-25 + H2O Rattus norvegicus i.e. synaptosome-associated protein of 25000 Da. One of the mechanisms by which arsenite impairs insulin secretion is by decreasing the oscillations of free Ca2+, thus reducing calcium-dependent calpain-10 partial proteolysis of SNAP-25 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP-25 + H2O i.e. synaptosome-associated protein of 25000 Da. One of the mechanisms by which arsenite impairs insulin secretion is by decreasing the oscillations of free Ca2+, thus reducing calcium-dependent calpain-10 partial proteolysis of SNAP-25 Rattus norvegicus ?
-
 ?
SNAP-25 + H2O i.e. synaptosome-associated protein of 25000 Da Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, diverse isoforms of calpain-10 are produced by alternative splicing. The isoform that shows the highest levels of expression is the one of approximately 50000 Da Rattus norvegicus