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Literature summary for 3.4.22.B30 extracted from

  • Rasbach, K.A.; Arrington, D.D.; Odejinmi, S.; Giguere, C.; Beeson, C.C.; Schnellmann, R.G.
    Identification and optimization of a novel inhibitor of mitochondrial calpain 10 (2009), J. Med. Chem., 52, 181-188.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CYGAK inhibitory activity of CYGAK to calpain 10 is independent of Ca2+ Rattus norvegicus
CYGAK disulfide valuable tool to prevent Ca2+ induced mitochondrial dysfunction and explore the function of calpain 10 Rattus norvegicus
CYGRK
-
Rattus norvegicus
CYGRKK
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion matrix Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
Rattus norvegicus ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.1
-
-
Rattus norvegicus CYGAK
0.24
-
-
Rattus norvegicus CYGRK
0.29
-
-
Rattus norvegicus CYGRKK