Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | mitochondrial calpain 10 is required for cell viability | Homo sapiens | 5739 | - |
mitochondrion | mitochondrial calpain 10 is required for cell viability | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | ? | - |
? | |
additional information | Rattus norvegicus | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | ? | - |
? | |
additional information | Mus musculus | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
Fischer 344 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | activity decreases in aging mouse kidney tissue | Mus musculus | - |
kidney | calpain 10 protein and mRNA levels decrease linearly in human kidney samples with age | Homo sapiens | - |
kidney | calpain 10 protein decreases in rat kidney samples with age, this decrease is attenuated with caloric restriction | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | Homo sapiens | ? | - |
? | |
additional information | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | Rattus norvegicus | ? | - |
? | |
additional information | mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney | Mus musculus | ? | - |
? |