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Literature summary for 3.4.22.B30 extracted from

  • Covington, M.D.; Arrington, D.D.; Schnellmann, R.G.
    Calpain 10 is required for cell viability and is decreased in the aging kidney (2009), Am. J. Physiol. Renal Physiol., 296, F478-F486.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Mus musculus 5739
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mitochondrion mitochondrial calpain 10 is required for cell viability Homo sapiens 5739
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mitochondrion mitochondrial calpain 10 is required for cell viability Rattus norvegicus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney ?
-
?
additional information Rattus norvegicus mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney ?
-
?
additional information Mus musculus mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
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Fischer 344
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney activity decreases in aging mouse kidney tissue Mus musculus
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kidney calpain 10 protein and mRNA levels decrease linearly in human kidney samples with age Homo sapiens
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kidney calpain 10 protein decreases in rat kidney samples with age, this decrease is attenuated with caloric restriction Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging human kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney Homo sapiens ?
-
?
additional information mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decrease in aging rat kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney Rattus norvegicus ?
-
?
additional information mitochondrial calpain 10 is required for cell viability. Calpain 10 levels specifically decreases in aging mouse kidney tissue when renal function decreases, suggesting that calpain 10 is required for renal function and is a biomarker of the aging kidney Mus musculus ?
-
?