Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Capn8-/- mice, that are fertile and whose gastric mucosae appears normal. However, the mutant mice are susceptible to gastric mucosal injury induced by ethanol administration, and the Capn8-/- stomach shows significant decreases in both calpains 9 and 8, and the same was true for Capn9-/-. Effects of calpain 8 deficiency on mucous granule formation and secretion, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91VA3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mucosa | gastric | Mus musculus | - |
stomach | calpain 8/nCL-2 is predominantly expressed in the gastrointestinal tract and is restricted to the gastric surface mucus cells in the stomach | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | enzyme domain structure with prodomain, protease domain, C2-like domain, and 5EF-hand domain | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
calpain 8/nCL-2 | - |
Mus musculus |
More | calpains constitute a superfamily of Ca2+-dependent cysteine proteases | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | calpain 8 is involved in vesicle trafficking between endoplasmic reticulum and Golgi. Calpain 8/nCL-2 is also involved in the mucosal defense against stress-induced gastropathies | Mus musculus |