Literature summary for 3.4.22.B14 extracted from

Niemeyer, D.; Moesbauer, K.; Klein, E.; Sieberg, A.; Mettelman, R.; Mielech, A.; Dijkman, R.; Baker, S.; Drosten, C.; Mueller, M.
The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species (2018), PLoS Pathog., 14, e1007296 .

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Organism

Organism	UniProt	Comment	Textmining
SARS coronavirus FRA	AY310120	isolated from Rhinolophus sp.	-

General Information

General Information	Comment	Organism
physiological function	insertion of a bat SARS-CoV PLP into the SARS-CoV genome. The resulting virus replicates like SARS-CoV in Vero cells but is suppressed in IFN competent MA-104 (3.7fold), Calu-3 (2.6fold) and human airway epithelial cells (10.3fold). A protease-independent, anti-IFN function exists in SARS-CoV, but not in a SARS-related, bat-borne virus	SARS coronavirus FRA

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Release 2023.1 (January 2023)