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Literature summary for 3.4.22.8 extracted from
- Sensitivity of Escherichia coli succinyl-CoA mutants at Trp beta 76 to clostripain and to trypsin. ADP and ATP protect against cleavage by clostripain at Arg beta 80 (1993), J. Biol. Chem., 268, 13717-13722.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | proteolysis of succinyl-CoA synthetase | Hathewaya histolytica |  |
| ATP | proteolysis of succinyl-CoA synthetase | Hathewaya histolytica | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Hathewaya histolytica | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA synthetase + H2O | the mutant forms of E. coli succinyl-CoA synthetase, W76F and W43,76,248F are more sensitive to proteolysis by clostripain than the wild-type enzyme. No influence of phosphorylation or dephosphorylation state. Argbeta80 is the principal site of inactivation by clostripain | Hathewaya histolytica | ? | - |
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