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Literature summary for 3.4.22.70 extracted from

  • Oh, K.; Kim, S.; Lee, J.; Cho, W.; Lee, T.; Kim, S.
    Discovery of diarylacrylonitriles as a novel series of small molecule sortase A inhibitors (2004), J. Med. Chem., 47, 2418-2421.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-2,3-bis(4-methoxyphenyl)acrylamide IC50: 0.476 mM Staphylococcus aureus
(2E)-2,3-bis(4-methoxyphenyl)acrylonitrile IC50: 0.187 mM Staphylococcus aureus
(2Z)-2,3-bis(4-methoxyphenyl)acrylonitrile IC50: 0.0279mM Staphylococcus aureus
(2Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile IC50: 0.009244 mM Staphylococcus aureus
(2Z)-3-(2-methoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile IC50: 0.0362 mM Staphylococcus aureus
(2Z)-3-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile IC50: 0.02296 mM Staphylococcus aureus
(2Z)-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile IC50: 0.025463 mM Staphylococcus aureus
(2Z)-3-(3-methoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile IC50: 0.0174 mM Staphylococcus aureus
methyl (2E)-2,3-bis(4-methoxyphenyl)acrylate IC50: 0.231 mM Staphylococcus aureus
methyl (2Z)-2,3-bis(4-methoxyphenyl)acrylate IC50: 0.909 mM Staphylococcus aureus
additional information no inhibition by trans-stilbene Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
ATCC 6538p, recombinantly expressed in Escherichia coli
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009244
-
IC50: 0.009244 mM Staphylococcus aureus (2Z)-3-(2,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
0.0174
-
IC50: 0.0174 mM Staphylococcus aureus (2Z)-3-(3-methoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
0.02296
-
IC50: 0.02296 mM Staphylococcus aureus (2Z)-3-(3,4-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
0.025463
-
IC50: 0.025463 mM Staphylococcus aureus (2Z)-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
0.0279
-
IC50: 0.0279mM Staphylococcus aureus (2Z)-2,3-bis(4-methoxyphenyl)acrylonitrile
0.0362
-
IC50: 0.0362 mM Staphylococcus aureus (2Z)-3-(2-methoxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
0.187
-
IC50: 0.187 mM Staphylococcus aureus (2E)-2,3-bis(4-methoxyphenyl)acrylonitrile
0.231
-
IC50: 0.231 mM Staphylococcus aureus methyl (2E)-2,3-bis(4-methoxyphenyl)acrylate
0.476
-
IC50: 0.476 mM Staphylococcus aureus (2E)-2,3-bis(4-methoxyphenyl)acrylamide
0.909
-
IC50: 0.909 mM Staphylococcus aureus methyl (2Z)-2,3-bis(4-methoxyphenyl)acrylate