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Literature summary for 3.4.22.70 extracted from

  • Ton-That, H.; Liu, G.; Mazmanian, S.K.; Faull, K.F.; Schneewind, O.
    Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif (1999), Proc. Natl. Acad. Sci. USA, 96, 12424-12429.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C184A mutant enzyme can not cleave the LPXTG motif Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Staphylococcus aureus the enzyme cleaves surface proteins of Staphylococcus aureus at the LPXT-/-G motif, catalyzes surface protein anchoring by means of a transpeptidation reaction that captures cleaved polypeptides as thioester enzyme intermediates ?
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?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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-
-

Purification (Commentary)

Purification (Comment) Organism
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Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Gln-Ala-Leu-Pro-Glu-Thr-Gly-Glu-Glu-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O
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Staphylococcus aureus 4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Gln-Ala-Leu-Pro-Glu-Thr + Gly-Glu-Glu-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid
-
?
additional information the enzyme cleaves surface proteins of Staphylococcus aureus at the LPXT-/-G motif Staphylococcus aureus ?
-
?
additional information the enzyme cleaves surface proteins of Staphylococcus aureus at the LPXT-/-G motif, catalyzes surface protein anchoring by means of a transpeptidation reaction that captures cleaved polypeptides as thioester enzyme intermediates Staphylococcus aureus ?
-
?