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Literature summary for 3.4.22.69 extracted from

  • Morse, J.; Lalonde, T.; Xu, S.; Liu, W.
    Learning from the Past Possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV (2020), ChemBioChem, 21, 730-738 .
    View publication on PubMed
Search for more literature for 3.4.22.69

Inhibitors

Inhibitors Comment Organism Structure
(2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
-
 Severe acute respiratory syndrome-related coronavirus
(4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one
-
 Severe acute respiratory syndrome-related coronavirus
5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione
-
 Severe acute respiratory syndrome-related coronavirus
5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione
-
 Severe acute respiratory syndrome-related coronavirus
Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide
-
 Severe acute respiratory syndrome-related coronavirus

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome-related coronavirus P0C6X7 human, i.e. SARS-CoV
-

Synonyms

Synonyms Comment Organism
3C-like peptidase
-
 Severe acute respiratory syndrome-related coronavirus
3cLpro
-
 Severe acute respiratory syndrome-related coronavirus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus Nalpha-[(2E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-D-phenylalaninamide
0.00104
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus 5-(4-methylpiperidine-1-sulfonyl)-1-phenyl-1H-indole-2,3-dione
0.00118
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus 5-(4-methylpiperidine-1-sulfonyl)-1H-indole-2,3-dione
0.0071
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus (2E)-1-[3-(2-hydroperoxy-3-methylbut-3-en-1-yl)-2-hydroxy-4-methoxyphenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
0.0362
-
 pH and temperature not specified in the publication Severe acute respiratory syndrome-related coronavirus (4E)-1,7-bis(3,4-dihydroxyphenyl)hept-4-en-3-one

General Information

General Information Comment Organism
physiological function the protease 3CLpro processes the polypeptide translation product from the genomic RNA into the structural and nonstructural protein components vital for the replication and packaging of a new generation of viruses Severe acute respiratory syndrome-related coronavirus