Any feedback?
Literature summary for 3.4.22.69 extracted from
- Processing of the SARS-CoV pp1a/ab nsp7-10 region (2020), Biochem. J., 477, 1009-1019 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| coronavirus polyprotein + H2O | Severe acute respiratory syndrome-related coronavirus | during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Severe acute respiratory syndrome-related coronavirus | P0C6X7 | human, i.e. SARS-CoV | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| coronavirus polyprotein + H2O | during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps | Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
| coronavirus polyprotein + H2O | during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps. There is a clear order of cleavage efficiencies, which is influenced by the polyprotein tertiary structure. The predominant product is an nsp7+8(2:2) hetero-tetramer with nsp8 scaffold | Severe acute respiratory syndrome-related coronavirus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| protease Mpro | - |
Severe acute respiratory syndrome-related coronavirus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps | Severe acute respiratory syndrome-related coronavirus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
