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Literature summary for 3.4.22.66 extracted from

  • Belliot, G.; Sosnovtsev, S.V.; Chang, K.O.; Babu, V.; Uche, U.; Arnold, J.J.; Cameron, C.E.; Green, K.Y.
    Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase (2005), J. Virol., 79, 2393-2403.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine norovirus precursor comprised of both the proteinase and polymerase (released from 3C-like proteinase) is a bifunctional enzyme during virus replication, which might be useful in the development of antiviral drugs of the noroviruses associated with acute gastroenteritis norovirus

Organism

Organism UniProt Comment Textmining
norovirus
-
-
-
norovirus MD145
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ORF1 polyprotein + H2O
-
 norovirus precursor comprised of both the proteinase and polymerase + mature polymerase
-
 ?
ORF1 polyprotein + H2O
-
 norovirus MD145 precursor comprised of both the proteinase and polymerase + mature polymerase
-
 ?

Synonyms

Synonyms Comment Organism
3C-like protease
-
 norovirus