Literature summary for 3.4.22.65 extracted from

Marconi, G.; Albertini, E.; Mari, A.; Palazzo, P.; Porceddu, A.; Raggi, L.; Bolis, L.; Lancioni, H.; Palomba, A.; Lucentini, L.; Lanfaloni, L.; Marcucci, F.; Falcinelli, M.; Panara, F.
In planta expression of a mature Der p 1 allergen isolated from an Italian strain of Dermatophagoides pteronyssinus (2012), Transgenic Res., 21, 523-535.

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Application

Application	Comment	Organism
diagnostics	possible development of diagnostic allergy tests based on in planta produced allergens using Der 1 p as prototype	Dermatophagoides pteronyssinus

Cloned(Commentary)

Cloned (Comment)	Organism
I-Der p 1 gene, cDNA isolation, DNA and amino acid sequence determination and analysis, detection of 11 polymorphisms to the sequence of peptidase 1, DERP1, UniProt ID P08176, sequence comparison, PVX-mediated expression of immunologically active mature form I-rDer p 1 in Nicotiana benthamiana plants using a Agrobacterium tumefaciens strain GV3101-mediated transfection strategy, the recombinant enzyme comprises the N-terminal 222 amino acids which corresponds to the mature form of I-Der p 1 after proteolytic cleavage, the C-terminus is expressed as FLAG-tagged protein	Dermatophagoides pteronyssinus

Cloned (Comment)

Organism

I-Der p 1 gene, cDNA isolation, DNA and amino acid sequence determination and analysis, detection of 11 polymorphisms to the sequence of peptidase 1, DERP1, UniProt ID P08176, sequence comparison, PVX-mediated expression of immunologically active mature form I-rDer p 1 in Nicotiana benthamiana plants using a Agrobacterium tumefaciens strain GV3101-mediated transfection strategy, the recombinant enzyme comprises the N-terminal 222 amino acids which corresponds to the mature form of I-Der p 1 after proteolytic cleavage, the C-terminus is expressed as FLAG-tagged protein

Dermatophagoides pteronyssinus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
25000	-	x * 25000, about, recombinant I-Der p 1, sequence calculation	Dermatophagoides pteronyssinus

Organism

Organism	UniProt	Comment	Textmining
Dermatophagoides pteronyssinus	B5AYU7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
feces	high concentration in mites faecal pellets	Dermatophagoides pteronyssinus	-

Subunits

Subunits	Comment	Organism
?	x * 25000, about, recombinant I-Der p 1, sequence calculation	Dermatophagoides pteronyssinus

Synonyms

Synonyms	Comment	Organism
Der p 1	-	Dermatophagoides pteronyssinus

General Information

General Information	Comment	Organism
additional information	binding properties of in tobacco plant-produced I-rDer p 1 versus the IgE of patients sera are comparable to those obtained on Der p 1 preparation immobilized on a microarray	Dermatophagoides pteronyssinus
physiological function	high enzyme concentration in mites faecal pellets can be airborne and, when inhaled, can cause perennial rhinitis and bronchial asthma in humans	Dermatophagoides pteronyssinus