Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chestnut cystatin | inhibits the enzyme and greatly increases the larval mortality | Dermatophagoides farinae | |
E-64 | - |
Dermatophagoides farinae | |
E-64 | - |
Dermatophagoides pteronyssinus | |
egg-white cystatin | - |
Dermatophagoides farinae | |
additional information | Der f1 from Dermatophagoides farinae is highly susceptible, Der p 1 from Dermatophagoides pteronyssinus is not affected by chestnut cystatin. Der p 1 inactivates chestnut chystatin by a specific proteolytic cleavage between Gly6 and Val7 | Dermatophagoides pteronyssinus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
casein | pH 6.5, 37°C | Dermatophagoides pteronyssinus | |
0.033 | - |
casein | pH 6.5, 30°C | Dermatophagoides farinae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Dermatophagoides farinae | allergen from Dermatophagoides farinae | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dermatophagoides farinae | - |
- |
- |
Dermatophagoides pteronyssinus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
azocasein + H2O | - |
Dermatophagoides pteronyssinus | ? | - |
? | |
casein + H2O | - |
Dermatophagoides farinae | ? | - |
? | |
casein + H2O | - |
Dermatophagoides pteronyssinus | ? | - |
? | |
chestnut cystatin + H2O | specific proteolytic cleavage between Gly6 and Val7, giving rise to a noninhibitory processed protein. Not cleaved by Der f 1 from Dermatophygoides farinae | Dermatophagoides pteronyssinus | ? | - |
? | |
additional information | allergen from Dermatophagoides farinae | Dermatophagoides farinae | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000031 | - |
chestnut cystatin | pH 6.5, 30°C | Dermatophagoides farinae |