Cloned (Comment) | Organism |
---|---|
gene CASP11, overexpression of FLAG-tagged enzyme in HEK-293T cells, co-expression with HA-tagged cationic channel subunit transient receptor potential channel 1, i.e. TRPC1, subunits p10 and p20 of caspase-11, but not caspase recruitment domain (CARD) alone, is co-immunoprecipitated with TRPC1. FLAG-tagged caspase-11 is able to co-immunoprecipitate independently with HA-tagged TRPC1 N-terminal alone, the N-terminal domain with the transmembrane domain, and the transmembrane domain with the C-terminal domain, but not with the central transmembrane domain alone | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cationic channel subunit transient receptor potential channel 1 + H2O | Mus musculus | i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses | ? | - |
? | |
cationic channel subunit transient receptor potential channel 1 + H2O | Mus musculus C57B6 | i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses | ? | - |
? | |
additional information | Mus musculus | other caspases are substrates of caspase-11 | ? | - |
? | |
additional information | Mus musculus C57B6 | other caspases are substrates of caspase-11 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus C57B6 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cationic channel subunit transient receptor potential channel 1 + H2O | - |
Mus musculus | ? | - |
? | |
cationic channel subunit transient receptor potential channel 1 + H2O | i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses | Mus musculus | ? | - |
? | |
cationic channel subunit transient receptor potential channel 1 + H2O | - |
Mus musculus C57B6 | ? | - |
? | |
cationic channel subunit transient receptor potential channel 1 + H2O | i.e. TRPC1, plays a role in regulating innate immunity by modulating channel complexes during inflammatory responses | Mus musculus C57B6 | ? | - |
? | |
additional information | other caspases are substrates of caspase-11 | Mus musculus | ? | - |
? | |
additional information | other caspases are substrates of caspase-11 | Mus musculus C57B6 | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
evolution | caspase-11 is a member of the caspase family of cysteine proteases | Mus musculus |
physiological function | caspase-11 is a highly inducible caspase that controls both inflammatory responses and cell death. Caspase-11 controls interleukin 1beta secretion by potentiating caspase-1 activation and induces caspase-1-independent pyroptosis downstream of noncanonical NLRP3 inflammasome activators such as lipopolysaccharide and Gram-negative bacteria. Caspase-11 modulates the cationic channel composition of the cell and thus regulates the unconventional secretion pathway in a manner independent of caspase-1. Caspase-11 controls the TRPC1-dependent decrease in cytosolic Ca2+ following lipopolysaccharide treatment | Mus musculus |