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Literature summary for 3.4.22.64 extracted from

  • Kayagaki, N.; Warming, S.; Lamkanfi, M.; Vande Walle, L.; Louie, S.; Dong, J.; Newton, K.; Qu, Y.; Liu, J.; Heldens, S.; Zhang, J.; Lee, W.P.; Roose-Girma, M.; Dixit, V.M.
    Non-canonical inflammasome activation targets caspase-11 (2011), Nature, 479, 117-121.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information targeting Casp11 exon 5 for deletion in C57BL/6 embryonic stem cells. Strain 129 mice, like Casp11-/- mutant mice, exhibits defects in IL-1beta production and harbours a mutation in the Casp11 locus that attenuates caspase-11 expression Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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gene Casp11
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Mus musculus C57BL/6
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gene Casp11
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage bone marrow-derived Mus musculus
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Synonyms

Synonyms Comment Organism
caspase-4
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Mus musculus

General Information

General Information Comment Organism
malfunction germline mutation of Casp11 in mouse strain 129 abolishes inflammasome activation by CTB. Strain 129 mice, like Casp11-/- mice, exhibits defects in IL-1beta production and harbours a mutation in the Casp11 locus that attenuates caspase-11 expression Mus musculus
physiological function caspase-11 mediates non-canonical inflammasome activation.Caspase-11 rather than caspase-1 is required for lipopolysaccharide-induced lethality. Interleukin-1beta secretion in response to other bacterial toxins, including adenylcyclase toxin, listeriolysin O toxin, or Clostridium difficile toxin B, is not affected by caspase-11 deficiency. Caspase-11 also is dispensable for NLRP3-dependent IL-1beta secretion in response to monosodium urate, calcium pyrophosphate, or the ionophore nigericin. In contrast, NLRP3- and ASC-dependent IL-1beta secretion from BMDMs infected with live Escherichia coli, Citrobacter rodentium and Vibriae cholerae, requires caspase-11, with or without lipopolysaccharide priming Mus musculus