Protein Variants | Comment | Organism |
---|---|---|
additional information | targeting Casp11 exon 5 for deletion in C57BL/6 embryonic stem cells. Strain 129 mice, like Casp11-/- mutant mice, exhibits defects in IL-1beta production and harbours a mutation in the Casp11 locus that attenuates caspase-11 expression | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene Casp11 | - |
Mus musculus C57BL/6 | - |
gene Casp11 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | bone marrow-derived | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
caspase-4 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | germline mutation of Casp11 in mouse strain 129 abolishes inflammasome activation by CTB. Strain 129 mice, like Casp11-/- mice, exhibits defects in IL-1beta production and harbours a mutation in the Casp11 locus that attenuates caspase-11 expression | Mus musculus |
physiological function | caspase-11 mediates non-canonical inflammasome activation.Caspase-11 rather than caspase-1 is required for lipopolysaccharide-induced lethality. Interleukin-1beta secretion in response to other bacterial toxins, including adenylcyclase toxin, listeriolysin O toxin, or Clostridium difficile toxin B, is not affected by caspase-11 deficiency. Caspase-11 also is dispensable for NLRP3-dependent IL-1beta secretion in response to monosodium urate, calcium pyrophosphate, or the ionophore nigericin. In contrast, NLRP3- and ASC-dependent IL-1beta secretion from BMDMs infected with live Escherichia coli, Citrobacter rodentium and Vibriae cholerae, requires caspase-11, with or without lipopolysaccharide priming | Mus musculus |