Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS | ? | - |
? | |
procaspase-1 + H2O | Mus musculus | - |
? | - |
? | |
procaspase-3 + H2O | Mus musculus | the enzyme is a critical initiator caspase responsible for the activation of caspase-3 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-11 can autoprocess itself in vitro | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | caspase-11 is upregulated in a subpopulation of cells i brain after ischemic injury | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | optimal cleavage site is IEHD, LEHD, VEHD or PEHD | Mus musculus | ? | - |
? | |
additional information | the enzyme is a critical initiator caspase responsible for the activation of caspase-3. The enzyme is an upstream activator of caspase-1. Caspase-11 deficient animals have a reduced number of apoptotic cells and a defect in caspase-3 activation after middle cerebral artery occlusion. The enzyme is A VERY IMPORTANT REGULATOR OF APOPTOSIS | Mus musculus | ? | - |
? | |
procaspase-1 + H2O | - |
Mus musculus | ? | - |
? | |
procaspase-1 + H2O | the enzyme is an upstream activator of caspase-1 | Mus musculus | ? | - |
? | |
procaspase-3 + H2O | - |
Mus musculus | ? | - |
? | |
procaspase-3 + H2O | the enzyme is a critical initiator caspase responsible for the activation of caspase-3 | Mus musculus | ? | - |
? |