Protein Variants | Comment | Organism |
---|---|---|
I406L | impairs apoptosis when transfected alone and dominantly inhibits apoptosis mediated by wild-type caspase-10 in a co-transfection assay | Homo sapiens |
L285F | impairs apoptosis when transfected alone and dominantly inhibits apoptosis mediated by wild-type caspase-10 in a co-transfection assay | Homo sapiens |
V410I | no dominant negative effect in co-transfection assay into H9 lymphocytic cell line. Protection from severe disease by caspase-10 V410I in 63 families with autoimmune lymphoproliferative syndrome Ia due to dominant Fas mutation | Homo sapiens |
Y446C | no dominant negative effect in co-transfection assay into H9 lymphocytic cell line | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome | Homo sapiens | ? | - |
? |