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Literature summary for 3.4.22.63 extracted from

  • Wang J.; Zheng L.; Lobito A.; Chan F.K.; Dale J.; Sneller M.; Yao X.; Puck J.M.; Straus S.E.; Lenardo M.J.
    Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II (1999), Cell, 98, 47-58.
    View publication on PubMed
Search for more literature for 3.4.22.63

Cloned(Commentary)

Cloned (Comment) Organism
expression of both the long and short isoforms of the wild-type or the caspase-10 mutants are transfected into Hela or MCF-7 cells together with a bet-gal reporter construct Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.071
-
 DEVD-7-amido-4-methylcoumarin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92851
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification autoprocessing, the wild-type 55000 Da GST fusion protein is cleaved to the 43000 Da active form Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DEVD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens DEVD + 7-amino-4-methylcoumarin
-
 ?
additional information inherited nonlethal caspase abnormalities cause pleiotropic apoptosis defects underlying autoimmunity in ALPS type II, caspase-10 mutations in Pt 11 and Pt 36 affect TRAIL-induced death of dendritic cells Homo sapiens ?
-
 ?
YVAD-7-amido-4-methylcoumarin + H2O less efficient cleavage than DEVD-7-amido-4-methylcoumarin Homo sapiens YVAD + 7-amino-4-methylcoumarin
-
 ?