Cloned (Comment) | Organism |
---|---|
cloning of caspase-10/c and caspase-10/d isoforms | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
perinuclear space | caspase-10/c is insoluble and localizes to filamentous perinuclear structures | Homo sapiens | - |
- |
soluble | caspase-10/a and caspase-10/d are soluble proteins | Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
x * 40000, caspase-10/c, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo, potential role of caspase-10/c in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is proteolytically active in vitro and also induces cell death ion vivo, although it is less active than Mch4. Possible role of caspase-10 family in the fetal development | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92851 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | caspase-10/c and caspase-10/d are splice isoforms. Caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase. Caspase-10/d is a hybrid of caspase-10/a (Mch4) and caspase-10/b (FLICE2), as it is identical to FLICE2 except for the small p12 catalytic subunit, which is identical to Mch4 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | fetal, activity is undetectable in the adult | Homo sapiens | - |
lung | fetal, activity is undetectable in the adult | Homo sapiens | - |
additional information | the expression levels of caspase-10-related mRNAs are generally higher in fetal than in adult tissues | Homo sapiens | - |
skeletal muscle | fetal, activity is undetectable in the adult | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspase-10/c is a truncated protein that is essentially a prodomain-only form of the caspase that lacks proteolytic activity in vitro but efficiently induces the formation of perinuclear filamentous structures and cell death in vivo, potential role of caspase-10/c in amplifying the apoptotic response to extracellular stimuli such as cytokines. Caspase-10/d is proteolytically active in vitro and also induces cell death ion vivo, although it is less active than Mch4. Possible role of caspase-10 family in the fetal development | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, caspase-10/c, SDS-PAGE | Homo sapiens |