Cloned (Comment) | Organism |
---|---|
proMch4 lacking the two N-terminal FADD-like domains is subcloned in the bacterial expression vector pET21b | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cowpox serpin CrmA | poorly inhibited | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | Mch4 mediates the CrmA-insensitive apoptotic pathways, such as the DNA-damaging agents and staurosporine pathways | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | proMch4 can autoprocess after Asp-219 and Asp-372 to generate the two subunits of the mature enzyme : P17, the large subunit and p12, the small subunit | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | broad specificity towards pro-aspartate-specific cysteine proteases | Homo sapiens | ? | - |
? | |
additional information | Mch4 mediates the CrmA-insensitive apoptotic pathways, such as the DNA-damaging agents and staurosporine pathways | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | proMch4 can autoprocess after Asp-219 and Asp-372 to generate the two subunits of the mature enzyme: P17, the large subunit and p12, the small subunit | Homo sapiens |