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Literature summary for 3.4.22.62 extracted from

  • Nie, C.; Luo, Y.; Zhao, X.; Luo, N.; Tong, A.; Liu, X.; Yuan, Z.; Wang, C.; Wei, Y.
    Caspase-9 mediates Puma activation in UCN-01-induced apoptosis (2014), Cell Death Dis., 5, e1495.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.62

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Bcl-2 + H2O Homo sapiens
-
 ?
-
 ?
BclxL + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A2780/CP cell
-
 Homo sapiens
-
A2780/S cell
-
 Homo sapiens
-
DLD-1 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
K-562/CP cell
-
 Homo sapiens
-
K-562/S cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Bcl-2 + H2O
-
 Homo sapiens ?
-
 ?
BclxL + H2O
-
 Homo sapiens ?
-
 ?

Expression

Organism Comment Expression
Homo sapiens siRNA Si Casp-9-1 efficiently inhibits caspase-9 expression down

General Information

General Information Comment Organism
malfunction caspase-9 inactivation by specific siRNA restrains the cleavage of Bcl-2 and Bcl-xL, inhibition of caspase-9 also prevents the degradation of Bcl-2 and Bcl-xL Homo sapiens
metabolism caspase-9 regulates Puma and caspase-3 activation in apoptosis in cancer cells Homo sapiens
physiological function caspase-9 induces feedback apoptosis of the mitochondrion by the cleavage of antiapoptotic Bcl-2 and Bcl-xL. Caspase-9 mediates Puma activation in protein kinase inhibitor 7-hydroxystaurosporine UCN-01-induced apoptosis, UCN-01 triggers Puma-induced mitochondrial apoptosis pathway, p53-independent Puma induction is pivotal for the anticancer effects of UCN-01. Caspase-9 enhances Puma activation by cleaving Bcl-2 and Bcl-xL independent of caspase-3. Caspase-9 also directly activates caspase-3 and apoptosis Homo sapiens