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Literature summary for 3.4.22.62 extracted from

  • Du, R.H.; Cui, J.T.; Wang, T.; Zhang, A.H.; Tan, R.X.
    Trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway (2012), Toxicon, 59, 143-150.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway, molecular mechanism, overview up

General Information

General Information Comment Organism
physiological function caspase-9 mediates activation of the mitochondrial death pathway, induced by trichothecin and leading to apoptosis of HepG2 cells with diminished expression of antiapoptotic protein Bcl-2 and enhanced expression of proapoptotic protein Bax at mRNA levels, molecular mechanism, overview. The decrement of mitochondrial function results from the overloaded calcium and ROS production Homo sapiens