Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway, molecular mechanism, overview | up |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase-9 mediates activation of the mitochondrial death pathway, induced by trichothecin and leading to apoptosis of HepG2 cells with diminished expression of antiapoptotic protein Bcl-2 and enhanced expression of proapoptotic protein Bax at mRNA levels, molecular mechanism, overview. The decrement of mitochondrial function results from the overloaded calcium and ROS production | Homo sapiens |