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Literature summary for 3.4.22.62 extracted from
- Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents (2011), Cell Cycle, 10, 3337-3345.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| casp9 | - |
Homo sapiens |
| caspase 9 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | caspase-9 is initiator in the mitochondrial pathway. Cyt-c and dATP bind in the cytoplasm to an adaptor protein named Apaf-1 and promote formation of the multi-protein apoptosome complex that binds the pro-casp-9. Consequently pro-casp-9 oligomerizes within this complex and is activated by it own autocleavage. In addition to its function as initiator of the mitochondrial apoptotic cascade, caspase-9 can acts also as an executer which among other non-apoptotic functions it forms an Sp1-p53 complex that activates the long terminal repeats by binding to an Sp1 recognition site residing in the long terminal repeats. Ectopic casp-9 but not ectopic casp-3 activates the LTR expression and induces the Sp1-p53 complex formation and its binding to the ERR-1 oligonucleotide | Homo sapiens |
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