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Literature summary for 3.4.22.62 extracted from

  • Levenbrown, Y.; Ashraf, Q.M.; Maounis, N.; Mishra, O.P.; Delivoria-Papadopoulos, M.
    Phosphorylation of caspase-9 in the cytosolic fraction of the cerebral cortex of newborn piglets following hypoxia (2008), Neurosci. Lett., 447, 96-99.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol mitochondrial fraction of cerebral tissue Sus scrofa 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
pro-caspase-9, Western blot, increased in hypoxic animals Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Sus scrofa modification at Ser196 results in alterations of proteolytic cleavage of procaspase-9 and caspase-9 activity caspase-3 + ?
-
?
pro-caspase-9 + H2O Sus scrofa modification at Ser196 results in alterations of proteolytic cleavage of procaspase-9 and caspase-9 activity caspase-9
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
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newborn piglets, aged 2-5 days
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation on Ser196 in hypoxic animals increased Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex mitochondrial fraction of cerebral tissue, hypoxia-treated, classified into a normoxic group and a hypoxic group Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
increased activity of caspase-9 during hypoxia, significant increase in the phophorylation on Ser196 during hypoxia, modification at Ser196 results in alterations of proteolytic cleavage of procaspase-9 and caspase-9 activity Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-caspase-3 + H2O modification at Ser196 results in alterations of proteolytic cleavage of procaspase-9 and caspase-9 activity Sus scrofa caspase-3 + ?
-
?
pro-caspase-9 + H2O modification at Ser196 results in alterations of proteolytic cleavage of procaspase-9 and caspase-9 activity Sus scrofa caspase-9
-
?