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Literature summary for 3.4.22.62 extracted from

  • Tichy, A.; Zaskodova, D.; Pejchal, J.; Rezacova, M.; Osterreicher, J.; Vavrova, J.; Cerman, J.
    Gamma irradiation of human leukaemic cells HL-60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9 (2008), Int. J. Radiat. Biol., 84, 523-530.
    View publication on PubMed

Application

Application Comment Organism
pharmacology studies on mechanisms of apoptosis induced by ionizing radiation in human leukaemic cells with a different status of p53 (TP53 tumor suppressor gene) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Homo sapiens mechanisms of apoptosis induced by ionizing radiation on cell lines with a different status of p53 (TP53 tumor suppressor gene), extrinsic (caspase-8 dependent) and intrinsic (caspase-9 dependent) pathways activated caspase-3 + ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55211
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell null mutant of protein p53 Homo sapiens
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MOLT-4 cell intact protein p53 Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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mechanisms of apoptosis induced by ionizing radiation on cell lines with a different status of p53 (TP53 tumor suppressor gene), activity of initial caspases (-8 and -9) analyzed by Western-Blot of whole-cell lysates and mitochondrial fractions, cells lacking the p53 protein show activation of caspase-8 prior to activation of caspase-9, cells harboring the p53 protein show a simultaneous activation of both initial caspases, extrinsic (caspase-8 dependent) and intrinsic (caspase-9 dependent) pathways activated upon exposure ionizing radiation regardless to the status of p53 protein Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-caspase-3 + H2O mechanisms of apoptosis induced by ionizing radiation on cell lines with a different status of p53 (TP53 tumor suppressor gene), extrinsic (caspase-8 dependent) and intrinsic (caspase-9 dependent) pathways activated Homo sapiens caspase-3 + ?
-
?