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Literature summary for 3.4.22.62 extracted from

  • Laguna, A.; Aranda, S.; Barallobre, M.J.; Barhoum, R.; Fernandez, E.; Fotaki, V.; Delabar, J.M.; de la Luna, S.; de la Villa, P.; Arbones, M.L.
    The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development (2008), Dev. Cell, 15, 841-853.
    View publication on PubMed
Search for more literature for 3.4.22.62

Application

Application Comment Organism
medicine dysregulation of the apoptotic response in differentiating neurons participates in the neuropathology of diseases that display with an imbalance of DYRK1A gene-dosage Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information plasmids pGFP-CASP9 WT/C287/T125 and pGST-CASP9 WT/T125 generated by site-directed mutagenesis Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information the protein kinase DYRK1A is a negative regulator of the intrinsic apoptotic pathway in the developing retina by phosphorylating caspase-9 on the inhibitory threonine residue 125 to prevent activation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus phosphorylation of caspase-9 at Thr125 by the protein kinase DYRK1A inhibits its cleavage and activation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9R0T0 Dyrk1A+/- and tgYAC152f7 genotypes
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phophorylation of the inhibitory threonine residue 125, catalyzed by the protein kinase DYRK1A Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
retina developing and adult Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 protein kinase DYRK1A is a negative regulator of the intrinsic apoptotic pathway in the developing retina, DYRK1A phosphorylates caspase-9 on threonine residue 125, phosphorylation crucial to protect retina cells from apoptotic cell death, dysregulation of the apoptotic response in differentiating neurons with an imbalance effects of DYRK1A gene-dosage participates in the neuropathology of diseases Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphorylation of caspase-9 at Thr125 by the protein kinase DYRK1A inhibits its cleavage and activation Mus musculus ?
-
 ?