Literature summary for 3.4.22.62 extracted from

Cepero, E.; King, A.M.; Coffey, L.M.; Perez, R.G.; Boise, L.H.
Caspase-9 and effector caspases have sequential and distinct effects on mitochondria (2005), Oncogene, 24, 6354-6366.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	activated caspase-9 prevents the accessibility of cytochrome c to complex III, resulting in the production of reactive oxygen species, and that effector caspases may depolarize mitochondria to terminate ROS production and preserve an apoptotic phenotype	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pre-B-cell	FL5.12	Mus musculus	-
pro-B-lymphocyte cell line	FL5.12	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	activated caspase-9 prevents the accessibility of cytochrome c to complex III, resulting in the production of reactive oxygen species, and that effector caspases may depolarize mitochondria to terminate ROS production and preserve an apoptotic phenotype	Mus musculus	?	-	?

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Release 2023.1 (January 2023)