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Literature summary for 3.4.22.62 extracted from
- Inhibition of human caspases by peptide-based and macromolecular inhibitors (1998), J. Biol. Chem., 273, 32608-32613.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-AEVD-CHO | - |
Homo sapiens |  |
| acetyl-DEVD-CHO | - |
Homo sapiens | |
| acetyl-IETD-CHO | - |
Homo sapiens | |
| acetyl-WEHD-CHO | - |
Homo sapiens | |
| acetyl-YVAD-CHO | - |
Homo sapiens | |
| benzyloxycarbonyl-VAD-fluoromethylketone | t1/2 at 0.001 mM is 3.9 s | Homo sapiens | |
| cowpox serpin CrmA | the Ki-value is below 2.3 nM | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000048 | - |
acetyl-AEVD-CHO | pH 7.5, 25°C | Homo sapiens | |
| 0.00006 | - |
acetyl-DEVD-CHO | pH 7.5, 25°C | Homo sapiens | |
| 0.000108 | - |
acetyl-IETD-CHO | pH 7.5, 25°C | Homo sapiens | |
| 0.000508 | - |
acetyl-WEHD-CHO | pH 7.5, 25°C | Homo sapiens | |
| 0.00097 | - |
acetyl-YVAD-CHO | pH 7.5, 25°C | Homo sapiens | |
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