Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O89110 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Casp8 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | failure to express caspase-8 has no effect on the life-span of dendritic cells but instead leads to an enhanced intrinsic activation and subsequently more mature and autoreactive lymphocytes. Mice with conditional deletion of caspase-8 in DCs develop a chronic systemic autoimmune disease | Mus musculus |
physiological function | caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation | Mus musculus |