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Literature summary for 3.4.22.61 extracted from

  • Cuda, C.M.; Misharin, A.V.; Gierut, A.K.; Saber, R.; Haines, G.K.; Hutcheson, J.; Hedrick, S.M.; Mohan, C.; Budinger, G.S.; Stehlik, C.; Perlman, H.
    Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation (2014), J. Immunol., 192, 5548-5560.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus O89110
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
Casp8
-
Mus musculus

General Information

General Information Comment Organism
malfunction failure to express caspase-8 has no effect on the life-span of dendritic cells but instead leads to an enhanced intrinsic activation and subsequently more mature and autoreactive lymphocytes. Mice with conditional deletion of caspase-8 in DCs develop a chronic systemic autoimmune disease Mus musculus
physiological function caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation Mus musculus