Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-IETD-fluoromethylketone | - |
Homo sapiens | |
Z-VAD-fluoromethylketone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | procaspase-8 is part of the trans-plasma membrane death-inducing signaling complex and is located on the cytosolic side. The activated enzyme is then released from the complex as caspase-8 | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bid + H2O | Homo sapiens | i.e. BH3 interacting domain death agonist | tBid + ? | - |
? | |
caspase-3 + H2O | Homo sapiens | - |
? | - |
? | |
interleukin-21 + H2O | Homo sapiens | - |
? | the CASP8-cleaved form of IL21R does not induce phosphorylation at Tyr705 of STAT3 | ? | |
vezatin + H2O | Homo sapiens | cleaved at Asp655 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Bid + H2O | i.e. BH3 interacting domain death agonist | Homo sapiens | tBid + ? | - |
? | |
carbonic anhydrase XIV + H2O | cleaved at Asp53 | Homo sapiens | ? | - |
? | |
caspase-3 + H2O | - |
Homo sapiens | ? | - |
? | |
interleukin-21 + H2O | - |
Homo sapiens | ? | the CASP8-cleaved form of IL21R does not induce phosphorylation at Tyr705 of STAT3 | ? | |
interleukin-21 + H2O | cleaved at Asp344 | Homo sapiens | ? | - |
? | |
additional information | generation of an NCtagged sTMP library and screening for CASP8 substrates, CASP8-cleavable sTMPs in the sTMP library, overview. Determination of cleavage sites by amino acid sequencing, consensus-type sequences are X-E/Q-X-D;-G/S, with X being any amino acid | Homo sapiens | ? | - |
? | |
vezatin + H2O | cleaved at Asp655 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Casp8 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | caspase-8 cleavage of the interleukin-21, IL-21, receptor is a negative feedback regulation of IL-21 signaling. Caspase-3 and the BH3 interacting domain death agonist, Bid, are cleaved by CASP8 as part of the apoptotic pathway | Homo sapiens |