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Literature summary for 3.4.22.61 extracted from
- Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways (2010), Nutrition, 26, 653-661.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzyloxycarbonyl-IETD-fluoromethylketone | specific inhibitor of caspase-8 | Homo sapiens |  |
| benzyloxycarbonyl-VAD-fluoromethylketone | pan-caspase inhibitor | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | - |
Homo sapiens | - |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | 4 mM butyrate and propionate but not acetate can induce non-activated and lipopolysaccharide- or tumor necrosis factor-alpha-activated neutrophil apoptosis by caspase-8 pathway | up |
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