Literature summary for 3.4.22.61 extracted from

Chae, S.S.; Yoo, C.B.; Jo, C.; Yun, S.M.; Jo, S.A.; Koh, Y.H.
Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis (2010), J. Neurosci. Res., 88, 1926-1933.

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Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-IETD-fluoromethylketone	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H4-C99 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Casp8	-	Homo sapiens
caspase 8	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	staurosporine-induced apoptosis induces caspase-8 activation	up

General Information

General Information	Comment	Organism
malfunction	depletion of caspase-8 decreases endogenous amyloid beta-protein production	Homo sapiens
physiological function	caspase-8 is involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis	Homo sapiens

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Release 2023.1 (January 2023)