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Literature summary for 3.4.22.61 extracted from

  • Couturier, J.; Morel, M.; Pontcharraud, R.; Gontier, V.; Fauconneau, B.; Paccalin, M.; Page, G.
    Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice (2010), J. Biol. Chem., 285, 1272-1282.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procaspase-3 + H2O Mus musculus
-
caspase-3 + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
LETD-4-nitroanilide + H2O
-
Mus musculus LETD + 4-nitroaniline
-
?
procaspase-3 + H2O
-
Mus musculus caspase-3 + ?
-
?

Expression

Organism Comment Expression
Mus musculus the activity of caspase-8 increases about 50-60% in amyloid-beta peptide-treated cells compared to untreated cells up

General Information

General Information Comment Organism
physiological function the Fas-associated protein with a death domain and subsequent activated caspase-8 are responsible for double-stranded RNA-dependent protein kinase-induced apoptosis in recombinant virus-infected cells Mus musculus