Literature summary for 3.4.22.61 extracted from

Chen, Y.W.; Lin, G.J.; Chia, W.T.; Lin, C.K.; Chuang, Y.P.; Sytwu, H.K.
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo (2009), Oral Oncol., 45, 562-568.

Search for more literature for 3.4.22.61

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	caspase-8 is activated downstream of the death receptor signaling or via death receptor-independent pathway	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
triptolide	a diterpenoid triepoxide derived from the herb Tripterygium wilfordii that is used as a natural medicine in China, activates caspase-8 4-6fold in pituitary adenoma cancer cells within 2 days, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	caspase-8 is activated downstream of the death receptor signaling or via death receptor-independent pathway	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
KB cell	-	Homo sapiens	-
OECM-1 cell	-	Homo sapiens	-
pituitary adenoma cell	-	Homo sapiens	-
SCC-25 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	caspase-8 is activated downstream of the death receptor signaling or via death receptor-independent pathway	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)