Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Delloye-Bourgeois, C.; Brambilla, E.; Coissieux, M.M.; Guenebeaud, C.; Pedeux, R.; Firlej, V.; Cabon, F.; Brambilla, C.; Mehlen, P.; Bernet, A.
    Interference with netrin-1 and tumor cell death in non-small cell lung cancer (2009), J. Natl. Cancer Inst., 101, 237-247.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information H-358 cells are transfected with a dominant negative mutant for caspase-8, DNC8, in combination with either scrambled siRNA or netrin-1 siRNA, expression of a dominant negative mutant of caspase-8 does not reverse the effect of netrin-1 targeting with caspase-3 activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IETD-fluoromethyl ketone a caspase-8-specific inhibitor Homo sapiens
N-benzyloxycarbonyl-VAD-fluoromethyl ketone a general caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens netrin-1 siRNA-induced H-358 cell death is mediated by caspase-3 and -9 activities, but not by caspase-8 activity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-
NCI-H358 cell
-
Homo sapiens
-
non-small cell lung cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information netrin-1 siRNA-induced H-358 cell death is mediated by caspase-3 and -9 activities, but not by caspase-8 activity Homo sapiens ?
-
?