Protein Variants | Comment | Organism |
---|---|---|
additional information | H-358 cells are transfected with a dominant negative mutant for caspase-8, DNC8, in combination with either scrambled siRNA or netrin-1 siRNA, expression of a dominant negative mutant of caspase-8 does not reverse the effect of netrin-1 targeting with caspase-3 activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
IETD-fluoromethyl ketone | a caspase-8-specific inhibitor | Homo sapiens | |
N-benzyloxycarbonyl-VAD-fluoromethyl ketone | a general caspase inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | netrin-1 siRNA-induced H-358 cell death is mediated by caspase-3 and -9 activities, but not by caspase-8 activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
NCI-H358 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | netrin-1 siRNA-induced H-358 cell death is mediated by caspase-3 and -9 activities, but not by caspase-8 activity | Homo sapiens | ? | - |
? |