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Literature summary for 3.4.22.61 extracted from

  • Kadohara, K.; Nagumo, M.; Asami, S.; Tsukumo, Y.; Sugimoto, H.; Igarashi, M.; Nagai, K.; Kataoka, T.
    Caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells (2009), J. Biol. Chem., 284, 5478-5487.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information caspase-8-deficient cells and their transfectants express slightly decreased levels of Fas compared with wild-type cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens The cysteine protease caspase-8 plays an essential role in apoptosis induced by death receptors, caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells. Bid is cleaved not by caspase-8 but by other caspases in Ac-CHX-treated cells and is not involved in mitochondrial release of proapoptotic proteins ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information The cysteine protease caspase-8 plays an essential role in apoptosis induced by death receptors, caspase-8 mediates mitochondrial release of pro-apoptotic proteins in a manner independent of its proteolytic activity in apoptosis induced by the protein synthesis inhibitor acetoxycycloheximide in human leukemia Jurkat cells. Bid is cleaved not by caspase-8 but by other caspases in Ac-CHX-treated cells and is not involved in mitochondrial release of proapoptotic proteins Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cysteine protease caspase-8
-
 Homo sapiens