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Literature summary for 3.4.22.61 extracted from

  • Hu, G.; Barnes, B.J.
    IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway (2009), J. Biol. Chem., 284, 2767-2777.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the interferon regulatory factor 5, IRF-5, induces caspase-8 activation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing of endogenous interferon regulatory factor 5, IRF-5, gives about 70% decrease in TRAIL-induced caspase-8 activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus nuclear colocalization of caspase-8 and Fas-associated death domain, FADD Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens interferon regulatory factor 5, IRF-5, promotes apoptosis upon signaling through tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, death receptors, DR. IRF-5 is involved in DR signaling upstream of caspase-8 and induces caspase-8 activation, mechanisms, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification procaspase-8 is activated by cleavage to caspase-8, induced by TRAIL, inhibited by IRF-5 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information interferon regulatory factor 5, IRF-5, promotes apoptosis upon signaling through tumor necrosis factor-related apoptosis-inducing ligand, TRAIL, death receptors, DR. IRF-5 is involved in DR signaling upstream of caspase-8 and induces caspase-8 activation, mechanisms, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
caspase 8
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Homo sapiens