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Literature summary for 3.4.22.61 extracted from

  • Jia, J.; Guan, D.; Zhu, W.; Alkayed, N.J.; Wang, M.M.; Hua, Z.; Xu, Y.
    Estrogen inhibits Fas-mediated apoptosis in experimental stroke (2009), Exp. Neurol., 215, 48-52.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information caspase-8 is induced in brain by cerebral ischemia. Upon activation, the cytoplasmic adaptor protein Fas-associated death domain associates with the death domain of Fas, followed by recruitment and activation of caspase-8 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus caspase-8 is involved in apoptosis, ischemia upregulates cytoplasmic adaptor protein Fas-associated Fas and Fas-associated death domain, FADD, expression, and increases caspase-8 and -3 activities in ovariectomy female mouse cortex, which are significantly attenuated by estradiol ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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cerebral cortex ipsilateral side Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IETD-7-amido-4-trifluoromethylcoumarin + H2O a specific caspase-8 substrate Mus musculus IETD + 7-amino-4-trifluoromethylcoumarin
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 ?
additional information caspase-8 is involved in apoptosis, ischemia upregulates cytoplasmic adaptor protein Fas-associated Fas and Fas-associated death domain, FADD, expression, and increases caspase-8 and -3 activities in ovariectomy female mouse cortex, which are significantly attenuated by estradiol Mus musculus ?
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 ?