Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no activation by methotrexate | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | methotrexate-induced apoptosis does not involve activation of caspase-8, but of caspase-9, overview. Caspase-8 is recruited to an apoptosis-inducing signaling complex when apoptotic receptors are oligomerized after binding of specific ligands. Active caspase-8 can either act directly on downstream executioner caspases, or indirectly on mitochondria | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
choriocarcinoma cell | - |
Homo sapiens | - |
JAR cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | methotrexate-induced apoptosis does not involve activation of caspase-8, but of caspase-9, overview. Caspase-8 is recruited to an apoptosis-inducing signaling complex when apoptotic receptors are oligomerized after binding of specific ligands. Active caspase-8 can either act directly on downstream executioner caspases, or indirectly on mitochondria | Homo sapiens | ? | - |
? |