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Literature summary for 3.4.22.61 extracted from

  • Chen, Y.X.; Lv, W.G.; Chen, H.Z.; Ye, F.; Xie, X.
    Methotrexate induces apoptosis of human choriocarcinoma cell line JAR via a mitochondrial pathway (2009), Eur. J. Obstet. Gynecol. Reprod. Biol., 143, 107-111.
    View publication on PubMed
Search for more literature for 3.4.22.61

Activating Compound

Activating Compound Comment Organism Structure
additional information no activation by methotrexate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens methotrexate-induced apoptosis does not involve activation of caspase-8, but of caspase-9, overview. Caspase-8 is recruited to an apoptosis-inducing signaling complex when apoptotic receptors are oligomerized after binding of specific ligands. Active caspase-8 can either act directly on downstream executioner caspases, or indirectly on mitochondria ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
choriocarcinoma cell
-
 Homo sapiens
-
JAR cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information methotrexate-induced apoptosis does not involve activation of caspase-8, but of caspase-9, overview. Caspase-8 is recruited to an apoptosis-inducing signaling complex when apoptotic receptors are oligomerized after binding of specific ligands. Active caspase-8 can either act directly on downstream executioner caspases, or indirectly on mitochondria Homo sapiens ?
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 ?