Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | TNF-related apoptosis-inducing ligand and etoposide induce caspase-8 activation, which is inhibited by caspase inhibitor N-carbobenzyloxy-VAD-fluoromethyl ketone, but not by M-791 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-carbobenzyloxy-VAD-fluoromethyl ketone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | caspases are a family of aspartate-specific cysteine proteases responsible for the biochemical and morphological changes that occur during the execution phase of apoptosis, model of the intrinsic pathway: caspase-9, the apical caspase, directly processes and activates the effector caspases, caspase-3 and -7, and then active caspase-3, but not caspase-7, processes caspase-2 and -6, and subsequently the activated caspase-6 processes caspase-8 and -10. Caspase-9 but not -8 is required for etoposide-induced processing of caspase-2 and -6. Caspase processing pathways and regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | procaspase-8 is cleaved in the cytoplasm by active caspase-6 and also by active caspase-3. After exposure to etoposide, caspase-8 is processed to its p43/41 forms, which arise following cleavage between the large and small subunits this processing is almost completely inhibited by N-carbobenzyloxy-VAD-fluoromethyl ketone even the lowest concentration used, whereas the lowest concentration of M-791 causes a partial inhibition of the processing of caspase-8, this is not substantially increased by higher M-791 concentrations | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | caspases are a family of aspartate-specific cysteine proteases responsible for the biochemical and morphological changes that occur during the execution phase of apoptosis, model of the intrinsic pathway: caspase-9, the apical caspase, directly processes and activates the effector caspases, caspase-3 and -7, and then active caspase-3, but not caspase-7, processes caspase-2 and -6, and subsequently the activated caspase-6 processes caspase-8 and -10. Caspase-9 but not -8 is required for etoposide-induced processing of caspase-2 and -6. Caspase processing pathways and regulation, overview | Homo sapiens | ? | - |
? |