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Literature summary for 3.4.22.61 extracted from

  • Fuchs, O.; Provaznikova, D.; Marinov, I.; Kuzelova, K.; Spicka, I.
    Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells (2009), Cardiovasc. Hematol. Disord. Drug Targets, 9, 62-77.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NPI-0052 the chemotherapeutic agent, i.e. salinosporamide A, a proteasome inhibitor, activates the caspase-8-dependent apoptosis pathway in multiple myeloma cells, it potentiates the apoptosis induced by TNF-alpha, bortezomib, and thalidomide, regulation, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
mantle cell lymphoma cell
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Homo sapiens
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multiple myeloma cell
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Homo sapiens
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