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Literature summary for 3.4.22.61 extracted from

  • Artwohl, M.; Lindenmair, A.; Roden, M.; Waldhaeusl, W.K.; Freudenthaler, A.; Klosner, G.; Ilhan, A.; Luger, A.; Baumgartner-Parzer, S.M.
    Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure (2009), Atherosclerosis, 202, 351-362.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
N-carbobenzyloxy-IETD-fluoromethyl ketone a specific caspase-8 inhibitor Homo sapiens
N-carbobenzyloxy-VAD-fluoromethyl ketone a pan-caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-8 is an initiator caspase. Procaspase-8 activation is essentially involved in apoptosis induced by selected nutritional free fatty acids, mechanisms, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information caspase-8 is an initiator caspase. Procaspase-8 activation is essentially involved in apoptosis induced by selected nutritional free fatty acids, mechanisms, overview Homo sapiens ?
-
 ?