Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.61 extracted from

  • Cheah, Y.H.; Nordin, F.J.; Tee, T.T.; Azimahtol, H.L.; Abdullah, N.R.; Ismail, Z.
    Antiproliferative property and apoptotic effect of xanthorrhizol on MDA-MB-231 breast cancer cells (2009), Anticancer Res., 28, 3677-3689.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information xanthorrhizol does not affect caspase-8 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information xanthorrhizol does not affect caspase-8 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens caspase-8, an initiator caspase, is not involved in MDA-MB-231 apoptotic cell death, overview. Caspase-8 is activated when procaspase-8 is cleaved subsequently from the recruitment of Fas associated protein with death domain, FADD, to the death-effector domain site of procaspase-8 during the oligomerization of death receptor and its ligand ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification caspase-8 is activated when procaspase-8 is cleaved subsequently from the recruitment of Fas associated protein with death domain, FADD, to the death-effector domain site of procaspase-8 during the oligomerization of death receptor and its ligand Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
MDA-MB-231 cell invasive breast cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ile-Glu-Thr-Asp-4-nitroanilide + H2O
-
Homo sapiens Ile-Glu-Thr-Asp + 4-nitroaniline
-
?
additional information caspase-8, an initiator caspase, is not involved in MDA-MB-231 apoptotic cell death, overview. Caspase-8 is activated when procaspase-8 is cleaved subsequently from the recruitment of Fas associated protein with death domain, FADD, to the death-effector domain site of procaspase-8 during the oligomerization of death receptor and its ligand Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens