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Literature summary for 3.4.22.61 extracted from
- Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8 (2004), Science, 304, 1500-1502.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | clinical therapies involving caspase inhibitors may arrest apoptosis, but also have the effect of promoting autophagic cell death | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzyloxycarbonyl-valyl-alanyl-aspartic acid (O-methyl)-fluoro-methylketone | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O89110 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| L-929 cell | L929 fibroblastic cell | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| receptor-indicating protein + H2O | separates the N-terminal kinase from the C-terminal death domain | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| caspase-8 | - |
Mus musculus |
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